2016 Fiscal Year Final Research Report
Persistent Intracellular Signaling Pathway as a Promising Therapeutic Target for Retinopathy of Prematurity
| Project/Area Number |
15K20260
|
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| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
|
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| Research Institution | Osaka University |
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Principal Investigator |
|
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 血管新生 / 内皮細胞 / 細胞内シグナル伝達分子 / 網膜 |
|---|
| Outline of Final Research Achievements |
Retinopathy of prematurity (ROP) is a vision-threatening disease in the retina of premature infants with incomplete retinal vascularization. In ROP, retinal vascular development stops and subsequently disorganized, fragile and leaky blood vessels grow. It has been studied that VEGF plays a critical role in the development of ROP. However, it remains unknown how endothelial cells alter responses to identical VEGF signaling in the growth of abnormal blood vessels. Here, we focused on long-lasting VEGF stimulation to reflect pathological condition, which induced persistent phosphorylation of Akt in cultured endothelial cells. Retinal blood vessels were dilated and leaky by the activation of Akt signaling pathway with transgenic mice. Therefore, molecules regulating persistent Akt activation can be potential targets for the treatment of ROP.
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| Free Research Field |
網膜血管新生
|
