Animal experiment with rodent model of non-arteritic ischemic optic neuropathy

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20269
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: University of Miyazaki
• Principal Investigator: Hidaka Takako 宮崎大学, 医学部, 助教 (00751140)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: レーザースペックルフローグラフィー / 非動脈炎性虚血性視神経症ラットモデル / 正常眼圧緑内障

Outline of Final Research Achievements

First, we measured intraocular pressure of normal rats and non-arteritic ischemic optic neuropathy rodent models(rNAION) using Tonolab tonometer. There was no significant difference between normal rats and rodent models. Second, we measured optic nerve head blood flow of normal rats and rNAION using Leser speckle flowgraphy. As a result, there was no significant difference of blood flow between right and left eyes in normal rats, and the left optic disc blood flow decreased in the acute and chronic phases of rNAION. Currently we are studying how to make a normal-tension glaucoma rat model by applying rNAION creation.

Free Research Field

緑内障