2018 Fiscal Year Final Research Report
| Project/Area Number |
15K20280
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Keywords | 落雪症候群 |
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| Outline of Final Research Achievements |
The healing of incisions in the corneal stroma was delayed compared to wild type mouse cornea in LOXl 1 knockout mice. Inflammatory cell infiltration appeared to be strong, but was considered a secondary finding with delayed healing. The results presented the need for analysis of cell behavior during the real healing process of LOXL1 and future issues. The healing of incisions in the corneal stroma was delayed compared to wild type mouse cornea in LOXl 1 knockout mice. Inflammatory cell infiltration appeared to be strong, but was considered a secondary finding with delayed healing. The results presented the need for analysis of cell behavior during the real healing process of LOXL1 and future issues.
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| Free Research Field |
水晶体
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| Academic Significance and Societal Importance of the Research Achievements |
落屑症候群ではLOXl1遺伝子の異常と発現低下が報告されている。LOXl1遺伝子異常の落屑症候群の病態分子メカニズムへの関与の実態は解明されていない。LOXファミリーメンバーのプロトタイプであるLOXにTGFb生理活性の抑制作用があることが報告されている。LOXl1が同様の作用を有しているか否かは報告が無いが、その同様の作用を有する可能性は大いに想定できる。解明できれば、落屑症候群の合併症である緑内障リスク、前嚢切開窓の線維化や濾過手術後の結膜瘢痕に対する対策にTGFbシグナル抑制の戦略が盛り込めると期待できる。
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