2016 Fiscal Year Final Research Report
Role of SIRT3 in age-related retinal diseases
| Project/Area Number |
15K20284
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Keio University |
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Principal Investigator |
Uchida Atsuro 慶應義塾大学, 医学部(信濃町), 特任助教 (70365336)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 網膜 / 老化 / 光 / 酸化ストレス / ミトコンドリア |
|---|
| Outline of Final Research Achievements |
SIRT3 knock out mice showed no obvious phenotype in the retina until 60 weeks old. However, they showed more severe light induced retinal degeneration compared with wild type mice. The levels of reactive oxygen species were higher and mitochondria had abnormality detected by electron microscopy after light exposure in the knock out mice.
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| Free Research Field |
網膜
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