The effect of bioactive protein for survival area of pedicled flap on the back of rat.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20315
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Iwate Medical University
• Principal Investigator: ARAI YUKIHIKO 岩手医科大学, 医学部, 助教 (20458178)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: ラミニン / 血管新生 / 皮弁遷延法

Outline of Final Research Achievements

Bioactive proteins, such as laminin, were reported that has an agiogenesis effect. Skin flap was raised on the back of rat, and a sheet conteining bioactive protein was placed on the wound in order to extend survival area of the skin flap. Both its angiogenesis and extending effect, however, were not clear. Survival area of the skin flaps are roughly corresponding to its perfusion area.
Then, a U-shaped skin flap was raised on the back of rat, and survival area of the skin flap was carefully observed by preserving blood vessels selectively. In bipedicle flap, 2 to 2.5 perfusion area from each vascular pedicle has limitations on survival. Additional blood vessels preserved at the center of this flap, seemed to be developing stability in the 2.5 perfusion area from vascular pedicle, even though they were cut in the second operation.

Free Research Field

医歯薬学