2016 Fiscal Year Final Research Report
The role of YAP/TAZ in scarless wound healing
| Project/Area Number |
15K20322
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Keio University |
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Principal Investigator |
Hamada Mariko 慶應義塾大学, 医学部(信濃町), 助教 (70723287)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 創傷治癒 / scarless wound healing / ケロイド / YAP/TAZ |
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| Outline of Final Research Achievements |
We examined keloid and normal tissue from 10 subjects and analyzing via IHC the YAP/TAZ levels in the cytoplasm and nucleus of keloid fibroblasts, endothelial cells and keratinocytes. The keloid fibroblast is the only cell that showed increased YAP/TAZ levels within the nucleus, possibly implicating this pathway in keloid pathogenesis and suggesting a potential target for therapeutic intervention.Our results suggest a possible pathway for keloid formation related to 'mechanotransduction' effects of stiffening of the ECM being signaled via YAP/TAZ expression influencing the Hippo pathway and keloid generation.
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| Free Research Field |
形成外科
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