The influence on intracranial aneurysm rupture by the fibrinolytic system control

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20338
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Kimura Tetsuro 浜松医科大学, 医学部附属病院, 助教 (00467250)
• Research Collaborator: MAKINO Hiroshi 浜松医科大学, 医学部附属病院, 講師 (10397408) ; IWAKI Takayuki 浜松医科大学, 医学部, 准教授 (70509463) ; HASHIMOTO Tomoki UCSF, Department of Anesthesia
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 脳動脈瘤 / 動物モデル / 画像解析 / 行動解析

Outline of Final Research Achievements

We studied the influence on intracranial aneurysm rupture by the fibrinolytic system control using the intracranial aneurysm mouse model, and also proceeded the evaluation of mouse aneurysm development and rupture.
1. We carried out the study by administration of tranexamic acid as an antifibrinolytic agent in advance. Currently, we are conducting the research using fibrinolytic genetically mice. 2. For mouse cerebral vessel imaging, we used 3-T magnetic resonance imaging (MRI) and saddle coil. We were able to detect the aneurysm formation using nonenhanced magnetic resonance angiography (MRA) and subarachnoid hemorrhage using T2-weighted imaging. 3. For detailed monitoring of aneurysm rupture, we developed a new video trapping application which could operate on the iPad. 4. In order to improve the safety of anesthesia after subarachnoid hemorrhage, we measured the minimal alveolar concentration of isoflurane of mice.

Free Research Field

脳循環