2016 Fiscal Year Final Research Report
Mechanism of the therapeutic effect of bromwarel urea on systemic immune response syndrome
| Project/Area Number |
15K20343
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Ehime University |
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Principal Investigator |
Kuwabara Jun 愛媛大学, 医学部附属病院, 助教 (00512162)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 敗血症 / シグナル伝達 |
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| Outline of Final Research Achievements |
BU has strong anti-inflammatory effects, which are not correlated with NFκB activation. BU has two distinct actions in association with anti-inflammatory effects: weak inhibition of LPS-induced STAT1 phosphorylation and IRF1 expression, and suppression of mitochondrial activities, leading to reduced iATP levels. Because the combination of rotenone and filgotinib suppressed NO release to a similar extent as BU, the marked anti-inflammatory effects of BU could be attributable to the synergistic effects of JAK1 inhibition and reduction in iATP. The mechanism behind BU’s effects on iATP contents and JAK1 activity remains to be clarified with future research.
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| Free Research Field |
救急医学
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