Differential diagnosis of fever using canonical discriminant analysis of innate immune receptor gene expression profiles

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20346
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Nagasaki University
• Principal Investigator: TAJIMA Goro 長崎大学, 病院(医学系), 助教 (00437427)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 自然免疫受容体 / 全身性炎症 / 判別分析

Outline of Final Research Achievements

Infection in patients with systemic inflammation is difficult to diagnose with a single biomarker. We aimed to clarify the time course of change in the gene expression profile of innate immune receptors in infectious or sterile inflammation and to establish an early diagnostic method using canonical discriminant analysis (CDA) of the gene expression profile.
Using murine peritonitis model and burn injury models, we compared the expression pattern of innate immune receptors. In the CDA, each group showed distinctive gene expression patterns at just 6 hours after injury. Each group was clearly classified, and the classification error rates were 0% at all of the time points. CDA of the gene expression profile of innate immune receptors could be a novel approach for diagnosing the pathophysiology of complicated systemic inflammation from the early stage of injury.

Free Research Field

救急医学