2017 Fiscal Year Final Research Report
Elucidation of a exacerbation mechanism of sepsis in acute ethanol intoxicaion
| Project/Area Number |
15K20351
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Nara Medical University |
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Principal Investigator |
Kasuda Shogo 奈良県立医科大学, 医学部, 講師 (70434941)
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| Research Collaborator |
KUDO Risa
YUUI Katsuya
SAKURAI Yoshihiko
HATAKE Katsuhiko
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 敗血症 / 急性アルコール中毒 |
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| Outline of Final Research Achievements |
We elucidated a mechanism of exacerbation mechanism of sepsis during acute ethanol intoxication in view of pentraxin 3 (PTX3) production. PTX3 is an acute phase protein, whose levels increase rapidly in response to inflammation. PTX3 production is triggered by TNF-α and is mediated by JNK phosphorylation. As PTX3 exerts protective effects on endothelial barrier integrity, it mitigates acute lung injury during sepsis.
We demonstrated that ethanol suppresses de novo PTX3 synthesis via two mechanisms; suppression of TNF-α production and inhibition of JNK phosphorylation.
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| Free Research Field |
血液凝固ー炎症反応連関からみた敗血症増悪機構
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