2016 Fiscal Year Final Research Report
Research of early diagnostic markers in septic shock
| Project/Area Number |
15K20353
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Kindai University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | 敗血症 / FAAH / アナンダマイド |
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| Outline of Final Research Achievements |
Anandamaide (ANA) is released from the cell extracellularly, taken into the cell again, and is hydrolyzed to arachidonic acid and ethanolamine by fatty acid amide hydrolase (FAAH). This metabolic enzyme of ANA is important to prevent overaccumulation of the ANA.Since Sequential organ failure assessment (SOFA) score and anandamaide are influenced by treatment such as Continuous hemodiafiltration (CHDF) after admisssion, it seems that it is not possible to reflect the condition of sepsis accurately in the course of treatment by SOFA and anandamide. The arachidonic acid cascade hydrolyzed and released by FAAH did not show any specific findings. When linolenic acid was increased at the time of admission, it was a result of poor prognosis. It seems that FAAH and linolenic acid system may be useful markers reflecting the condition of sepsis.
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| Free Research Field |
救急医学、集中治療医学、敗血症、感染症
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