2016 Fiscal Year Final Research Report
The role of macrophage SOCS3 in cardiac remodeling after myocardial infarction.
| Project/Area Number |
15K20355
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 急性心筋梗塞 / SOCS3 / サイトカイン |
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| Outline of Final Research Achievements |
The purpose of this study is to clarify the role of macrophage SOCS3 in acute myocardial infarction.Macrophage specific SOCS3-KO(SOCS-mKO) mice had high mortality more than control mice. This result suggests that macrophage SOCS3 has protective effect for myocardium after myocardial infarction. LV rupture rate after myocardial infarction was high in the SOCS3-mKO mice than in the control mice.Third day after myocardial infarction, myocardium internal hemorrhage was greater in SOCS3-mKO mice than in the control mice. We will evaluate MMP to clarify the mechanism of LV rupture.
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| Free Research Field |
循環器
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