Overcome the drug resistance of oral cancers with inhibition of transporters in tumor endothelial cells

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20357
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: Hokkaido University
• Principal Investigator: Akiyama Kosuke 北海道大学, 遺伝子病制御研究所, 客員研究員 (10609100)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: がん / 腫瘍血管 / 薬剤耐性

Outline of Final Research Achievements

Chemotherapy is one of the method of cancer therapy, but the therapeutic effect is not enough because of drug resistance. It has been reported that tumor endothelial cells (TECs) show abnormal phenotype. TECs are resistant to anti-cancer drug. In this study, we tried to inhibit transporters which is related to drug resistance. Treatment of paclitaxel with transporter inhibitor inhibited TEC proliferation in vitro. In addition, treatment of paclitaxel with transporter inhibitor inhibited tumor growth compared to single paclitaxel treatment.

Free Research Field

腫瘍血管新生