2017 Fiscal Year Final Research Report
The role of zinc tranporter ZnT4 in secretory function and pathology of salivary glands
| Project/Area Number |
15K20369
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Research Collaborator |
MISHIMA Kenji 昭和大学, 歯学部, 教授 (50275343)
IRIE Taro 岩手医科大学, 歯学部, 教授 (00317570)
YASUHARA Rika 昭和大学, 歯学部, 講師 (20453649)
TANAKA Junichi 昭和大学, 歯学部, 助教 (40710166)
FUKADA Toshiyuki 徳島文理大学, 薬学部, 教授 (70373363)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 亜鉛 / 唾液腺 / ZnT |
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| Outline of Final Research Achievements |
We determined the role of a zinc transporter, ZnT4, in salivary zinc secretion. In major salivary glands of wild type female mouse, expression level of ZnT4 in submandibular (SMG) and sublingual (SLG) glands were higher than parotid gland. Also, in situ hybridization detected that positive reaction in acinar and intercalated duct of SMG and SLG. In western blotting, ZnT4 positive band was detected in both SMG and mammary gland lysates. Therefore, ZnT4 was suggested that expressed in salivary glands. Next we used spontaneous mutant mice of ZnT4 (lm mouse) which is induced mammary gland degeneration by removal of additive zinc in drinking water. In result, removal of additive zinc in drinking water did not induce degeneration of submandibluar gland.
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| Free Research Field |
口腔病理学
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