The involvement of microglia and early molecular signaling in the jaw face of abnormal pain onset

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20378
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Functional basic dentistry
• Research Institution: Showa University
• Principal Investigator: Han In Yang (清本聖文) 昭和大学, 歯学部, 助教 (00712556)
• Research Collaborator: INOUE Tomio 昭和大学, 歯学部口腔生理学講座, 教授 (70184760) ; IWATA Kouichi 日本大学, 歯学部口腔生理学講座, 教授 (60160115) ; SHINODA Masamichi 日本大学, 歯学部口腔生理学講座, 准教授 (20362238) ; NAKAMURA Shiro 昭和大学, 歯学部口腔生理学講座, 准教授 (60384187) ; MOCHIZUKI Ayako 昭和大学, 歯学部口腔生理学講座, 助教 (10453648) ; NAKAYAMA Kiyomi 昭和大学, 歯学部口腔生理学講座, 講師 (10453648)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: microglia / 異所性異常疼痛 / 炎症 / 口腔顔面痛 / allodynia / 脊髄 / 三叉神経

Outline of Final Research Achievements

In clinical practice it may be encountered in patients complaining of maxillofacial part ectopic abnormal. Cervical inflammation and damage are considered as causes.In order to elucidate the molecular mechanism associated with the onset of allodynia, an inflammatory agent was administered to create model rat.Behavioral observation was carried out for 15 days, and on day 4, ectopic abnormal pain of the maxillofacial area skin was confirmed in the model group. The decrease in pain response at an earlier stage than before the 4th day was observed. In the immunohistological study, activation of microglia was recognized in the spinal cord of dominant region of maxillofacial region skin. From the study, it was suggested that there is a possibility of signal transmission between nerve and glia in the development of pain.
Unfortunately, this study could not identify early molecular signals and would like to expect further research.

Free Research Field

口腔生理学