2016 Fiscal Year Final Research Report
Development of pulp and hard tissue regeneration by the novel NF-kB inhibitor, MTI-II.
Project/Area Number |
15K20409
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Conservative dentistry
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Research Institution | Hiroshima University (2016) Kyushu Dental College (2015) |
Principal Investigator |
Tsuchiya Shizu 広島大学, 医歯薬保健学研究院(歯), 助教 (60610053)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | 炎症 / 硬組織 |
Outline of Final Research Achievements |
We have previously reported that the inflammatory cytokine, tumor necrosis factor α (TNFα) inhibits BMP-induced osteoblast differentiation via NF-κB signaling. In the present study, we examined the effects of a steroid-coactivator, Macromolecular Translocation Inhibitor II (MTI-II), on inflammatory responses(Endocrinology, 2016). MTI-II was previously demonstrated as an enhancer of the transcriptional activity of glucocorticoid-bound glucocorticoid receptor. We examined the effects of MTI-II on the inhibition of odontoblastogenesis by TNFα. When the cells were treated with TNFα, ALP activity was inhibited, while MTI-II restored TNFα-mediated inhibition of the activity in a dose-dependent manner (J Cell Biochem, 2016). MTI-II potentially acts as an anti-inflammatory drug.
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Free Research Field |
歯内治療学
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