2017 Fiscal Year Final Research Report
An investigation of local osteoclastgenesis through function of bone marrow cells
| Project/Area Number |
15K20431
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 破骨細胞 / 骨髄細胞 |
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| Outline of Final Research Achievements |
Based on the hypothesis that bone marrow derived cells in blood are indirectly involved in the control of local osteoclast differentiation and induction, we investigated the influence of supernatant of cultured BMSCs under various conditions on osteoclastogenesis, the expression of known osteoclast differentiation related factors expressed by BMSCs and we tried to identify the cell type that most expresses those factors. As a result, BMSCs cultured for a certain period on various surfaces had different properties on BMM differentiation to osteoclast. In addition, analysis of gene expression of BMSCs cultured on various surfaces by qPCR method confirmed that some cells in BMSCs produce factors that affect osteoclast differentiation.
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| Free Research Field |
歯科補綴学
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