Elucidation of the biological pathology of peri-implantitis and development of immunological therapy.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20439
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Okayama University
• Principal Investigator: Mino Takuya 岡山大学, 医歯薬学総合研究科, 助教 (10625718)
• Research Collaborator: 窪木 拓男 (00225195) ; 大野 充昭 (60613156) ; 大野 彩 (20584626)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 口腔インプラント / インプラント周囲炎 / 免疫応答 / 次世代シークエンサー / メタゲノム解析

Outline of Final Research Achievements

It is well known that peri-implantitis is caused by bacterial infection but the constitution of bacteria causing peri-implantitis is still unclear. We did cluster analysis of NGS to investigate the bacterial flora of peri-implant exudate which was extracted from 6 patients suffering from peri-implantitis. As a result, we found five kinds of bacteria in peri-implantitis site which were not found in periodontitis teeth, and another five kinds of bacteria which were not found in normal implants.

Free Research Field

歯科補綴学，口腔インプラント学