New developmet of extremely effective salivaly marker for diagnosis of oral dryness

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20456
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: The Nippon Dental University
• Principal Investigator: MIZUHASHI Fumi (高橋史) 日本歯科大学, 新潟生命歯学部, 准教授 (60386266)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 口腔乾燥症 / Ca拮抗薬 / タンパク同定解析 / RNA抽出 / マーカー

Outline of Final Research Achievements

Calcium antagonist are often used for the treatment of hypertension. There are many oral dryness patients who take the calcium antagonist. In this study, we investigated the specific protein and RNA to the oral dryness patients taking the calcium antagonist.
The results of this study was that the amount of salivary secretion decreased and the protein concentration increased in the oral dryness patients taking the calcium antagonist. The results of the global analysis of salivary protein in the oral dryness patients taking the calcium antagonist and healthy elderly subjects indicated that there are some specific proteins increasing or decreasing in the oral dryness patients taking the calcium antagonist.

Free Research Field

医歯薬学