2017 Fiscal Year Final Research Report
Development of adhesion inhibition method for Candida biofilm using competitive mechanism of adhesin-like polysaccharides
Project/Area Number |
15K20461
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Prosthodontics/ Dental materials science and
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Research Institution | Tsurumi University |
Principal Investigator |
SATO Maki 鶴見大学, 歯学部, 非常勤講師 (10712094)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | 義歯床用レジン / デンチャープラーク / バイオフィルム / Candida |
Outline of Final Research Achievements |
In this study, we examined the inhibitory effects of denture plate resin coatings on the adherence of Candida to the resin. Three adhesin-like polysaccharides (mannan, galactomannan, and β-glucan), which are structural components of the Candida cell wall, were used as coatings. A concentration-dependent inhibition of Candida adherence to the denture plate resin was observed in the groups coated with either 1 or 10 mg/ml mannan, but neither galactomannan nor β-glucan showed any inhibition effect. Similarly, chitosan, another structural component of the cell wall, which is known to have antimycotic properties, was applied to the denture plate resin, but no effect was observed over the period of this study.
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Free Research Field |
歯科補綴学
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