Development of regenerative therapy on bone and nerve tissue using dental pulp stem cell

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20494
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: HATA MASAKI 愛知学院大学, 歯学部, 講師 (20632871)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 歯髄幹細胞 / 細胞移植 / 顎骨欠損 / 糖尿病性神経障害

Outline of Final Research Achievements

In this study, we examined whether transplanted-DPSCs produce new bone and improve diabetic polyneuropathy. Rat-derived DPSCs were injected into a critical-sized bone on carvalial bone. The transplantation of DPSCs with Collagen showed bone formation starting from the edges as well as from the center of the defect. Human-derived DPSCs were injected into unilateral hindlimb skeletal muscles of streptozotocin-induced diabetic mouse. The transplantation of DPSCs improved the impaired sciatic nerve conduction velocity, sciatic nerve blood flow and sentation. These results revealed that DPSCs may be an effective regenerative therapy on bone and nerve tissue.

Free Research Field

医歯薬学