2016 Fiscal Year Final Research Report
Elucidation of the cancer progression through the a5b3 integrin pathway for establishment of a noval treatment for tumor growth
| Project/Area Number |
15K20502
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Keywords | α5β3integrin / Angiopietin-like3 / 口腔扁平上皮癌 |
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| Outline of Final Research Achievements |
Significant ANGPTL3 up-regulations were found in oral squamous cell carcinoma (OSCC) cell lines and primary OSCC patients compared with normal counterparts. Using ANGPTL3 knockdown cells, we revealed that decreased tumoral growth was closely correlated with cell-cycle arrest at the G1 phase via MAPK signaling cascades. In addition, ANGPL3 controlled α5β3 integrins in OSCCs, indicating that ANGPTL3 may play an important role in OSCC progression and diagnostic/therapeutic targets for the patients with OSCC.
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| Free Research Field |
医歯薬学
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