Biological functions of micro-cellular environment derived from stromal cells and its application for cartilage regeneration.

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20503
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: The University of Tokyo
• Principal Investigator: INAKI RYOKO 東京大学, 医学部附属病院, 特任研究員 (90632456)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 再生医療 / 軟骨再生 / 細胞周囲微小環境 / 間質細胞

Outline of Final Research Achievements

In transplantation model of tissue-engineered cartilage, a micro-cellular environment derived from stromal cells, which was called niche, formed around chondrocytes with tissue regeneration. In this study, biological functions of micro-cellular environment derived from stromal cells was investigated to clarify its effect on chondrocytes and tissue-engineered cartilage. The results showed that chondrocytes adjacent to stromal cells promoted the differentiation in transplantation model of tissue-engineered cartilage, and stromal cells co-localized with chondrocytes induced the expression of specific genes in vitro experiments. In cartilage regeneration, it was suggested that the construction of micro-cellular environment derived from stromal cells supported the differentiation of chondrocytes and the maturation of tissue-engineered cartilage.

Free Research Field

医歯薬学