2016 Fiscal Year Final Research Report
Elucidation of permeation, metastaticity acquisition mechanism due to the platelet in the tissue in oral squamous cell carcinoma
| Project/Area Number |
15K20510
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 口腔扁平上皮癌 / 血小板 / 上皮間葉移行 |
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| Outline of Final Research Achievements |
In order for cancer cells to metastasize and invade, it is important for cancer cells to develop epithelial mesenchymal transition (EMT) and to construct an immunosuppressive microenvironment around the tumor. In recent years, attention has been drawn that platelets in blood vessels coat cancer cells, induce EMT, and act to promote invasion, metastasis. In this study, we investigated the induction of epithelial mesenchymal transition by coculturing oral squamous cell carcinoma cell line and platelets. As a result, it is suggested that epithelial mesenchymal transition may occur. In addition, immunostaining of tissue specimens obtained from oral squamous cell carcinoma patients showed that tumors tended to have mesenchymal characteristics in cases with high invasiveness. And it is suggested that platelet aggregation may be caused around.
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| Free Research Field |
口腔外科
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