2016 Fiscal Year Final Research Report
Elucidation of the anti-inflammatory mechanism of dexmedetomidine - Analysis of arachidonate metabolism -
Project/Area Number |
15K20526
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Surgical dentistry
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Research Institution | Okayama University |
Principal Investigator |
Wakasugi Yuka 岡山大学, 医歯薬学総合研究科, 助教 (00749210)
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Research Collaborator |
MIYAKE Saki
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Keywords | 歯学 / 薬理学 |
Outline of Final Research Achievements |
This study aimed to clarify the mechanism of anti-inflammatory effect of dexmedetomidine (DEX). First, anti-inflammatory effect of DEX in Raw264.7 mouse macrophages was examined. Next, it was hypothesized that the production of EETs (epoxyeicosatrienoic acids), which are considered to have anti-inflammatory effect, increased via the arachidonic acid cascade by DEX, resulting in anti-inflammatory effect. Although anti-inflammatory effect of DEX was observed in Raw 264.7, the administration of DEX inhibited the production of EET. Thus, the finding suggests that the anti-inflammatory effect of DEX possibly is not via EETs production, but other pathway.
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Free Research Field |
歯科麻酔学
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