2017 Fiscal Year Final Research Report
Prospects of osteogenesis using adipose-derived MSCfat (ASC) and Fibrin seat.
| Project/Area Number |
15K20527
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 骨再生 |
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| Outline of Final Research Achievements |
Dedifferentiated fat cells (DFATs) and adipose stem cells (ASCs) have been reported to show the similar multilineage potential with bone marrow-derived mesenchymal stem cells (MSCs), and can be more easily harvested from mature adipose tissue than MSCs. ASCs are heterogenous cell populations of mesodermal stem cells with contamination by smooth muscle cells, blood cells, perithelial cells, and endothelial cells in particular at early passage. Compared to ASCs, DFATs can be dedifferentiated from mature adipocytes to fibroblast-like cells in vitro and show high proliferative and high homogeneous. Bone tissue engineering of DFATs and ASCs is expected for the regenerative medicine. The purpose of this study was to compare the osteogenic potent of DFATs and ASCs.
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| Free Research Field |
再生医療
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