Spatiotemporal Regulation of Adenoid Cystic Carcinoma Metastasis

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20537
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Ehime University
• Principal Investigator: MURASE RYUICHI 愛媛大学, 医学部附属病院, 講師 (70452696)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 時空間制御機構

Outline of Final Research Achievements

During metastasis, dynamic molecular change is potentially implicated in cancer cells. We focused on the spatiotemporal regulation of adenoid cystic carcinoma (ACC) metastasis. Unlike squamous cell carcinoma, reversible epithelial-mesenchymal transition was not observed in ACC, while several RNAs expressed transiently. This result may indicate that a specific molecular mechanism is essential for disseminated ACC cells to proliferate and form metastases.

Free Research Field

口腔腫瘍