2017 Fiscal Year Final Research Report
Functional mechanism of soluble RCAS1 in OSCC metastasis
| Project/Area Number |
15K20539
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 癌 / 口腔癌 / RCAS1 / リンパ節転移 |
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| Outline of Final Research Achievements |
Receptor-binding cancer antigen expressed on SiSo cell (RCAS1) expression is reportedly correlated with clinico-pathological parameters in 15 human cancers, such as lymph node metastasis. After proteolytic process, membranous RCAS1 is secreted to serum from tumor cells in some cancer. In Our study, membranous pattern were expressed in oral squamous cell carcinoma (OSCC) cell lines, while soluble pattern was detected in supernatants. Soluble RCAS1 were significantly seen in high metastatic potential OSCC cell more than the others. In addition, RCAS1 expression is effected to migration ability, thus contributing to tumor lymph node metastasis. To elucidate mechanism of lymph node metastasis in OSCC, it was strongly suggested that functional regulation of RCAS1.
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| Free Research Field |
医歯薬学
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