2017 Fiscal Year Final Research Report
Functional roles of DSCAM and netrin-1 in bone metabolism
| Project/Area Number |
15K20556
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | netrin / DSCAM / 骨芽細胞 |
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| Outline of Final Research Achievements |
We found that netrin-4 promotes osteoblast differentiation and migration, suggesting that netrin-4 plays vital roles in regulating bone metabolism. We showed that netrin-4 does not interact with DSCAM receptor and DSCAM knockout mice exhibit normal bone phenotype, indicating that DSCAM receptor does not play essential roles in bone metabolism.
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| Free Research Field |
口腔外科学
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