2017 Fiscal Year Final Research Report
Establishment of early diagnosis and immunological oral cancer
| Project/Area Number |
15K20570
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 口腔癌 / 前癌病変 / T細胞受容体 / EGFR / 上皮増殖因子 |
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| Outline of Final Research Achievements |
The host immune responses reflected by the TCR repertoire, differed between primary tumors and metastatic lymph nodes. Overexpression of the epidermal growth factor receptor (EGFR) family is common in oral squamous cell carcinoma (OSCC).These results suggest that lymph node metastasis might be associated with changes in the nature of the primary tumor antigens. The expression level of ErbB1 messenger RNA (mRNA) was markedly increased in OSCC. By comparing the gene expression levels of EGFR family members in OSCC tissues that had lymph node metastasis with those in the absence of lymph node metastasis, we found that ErbB4 mRNA expression was increased significantly. Moreover, we confirmed protein expression of ErbB4 in the cytoplasm and membrane of tumor cells, which was stronger in cases with lymph node metastasis. ErbB4 is an independent marker for lymph node metastasis in OSCC.
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| Free Research Field |
口腔外科
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