Does oral mucosal immune system contribute to Bisphosphonate-related osteonecrosis of the jaw?

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K20572
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Surgical dentistry
• Research Institution: Asahi University
• Principal Investigator: KANAYAMA KEIICHI 朝日大学, 歯学部, 講師 (20454275)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: ビスホスホネート関連顎骨壊死 / マウスモデル / 口腔粘膜免疫

Outline of Final Research Achievements

The number of patients with bisphosphonate-related osteonecrosis of the jaw itself is small, symptoms are severe when it develops and there is no causal treatment. A lot of research has been done to clarify the mechanism of BRONJ and it has also been suggested that immune cells are involved in the phenotype of BRONJ symptoms. We studied using the ONJ mouse model as to which immune cell's response the BRONJ phenotype shows various symptoms.

Free Research Field

歯周病態学

Academic Significance and Societal Importance of the Research Achievements

2014年に米国口腔顎顔面外科学会からMRONJに関するポジションペーパーが出され、従来の定義の変更がなされた。骨露出を認めるものに加え、骨露出のない瘻孔型のものも併記された。nBP長期使用患者数は年々累積していくなかTCRD-/-での結果は、gdT細胞と瘻孔型MRONJの表出との関連を示唆している。MRONJの病態解明にはgdT細胞の動態だけでなく口腔粘膜の免疫をつかさどるT細胞、B細胞、NK細胞の働きが鍵を握ると考える。そこで、成熟したT細胞・B細胞を欠損したRag2-/-マウスを使ってMRONJ症状の変化の検討を行った。