2017 Fiscal Year Final Research Report
Localization of stem cells in osteoarthritis of the temporomandibular and joint repair mechanism
| Project/Area Number |
15K20573
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Asahi University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 顎関節 / 幹細胞 / 老化促進マウス |
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| Outline of Final Research Achievements |
Senescence-Accelerated Mouse mice (SAM), SAMP 8 spontaneously develops osteoarthritis of the osteoarthritis, and the divided cells are labeled by administering BrdU (5-bromo-2'-deoxyuridine) for a certain period, After examining the localization of cells (LRCs) that kept labels in the temporomandibular joint after the administration period (2, 3 months), it was localized in joint capsule and ligament joint disc. In addition, it was confirmed that fluorescent immuno double staining was carried out using LRCs using the mesenchymal stem cell marker STRO-1, CD 146 antibody. In the temporomandibular joint of SAMP 8, the cartilage surface roughened and morphology of the mandibular head was observed. The length of the mandibular branch decreased as compared with the control group SAMR1. From the TMJ model, STRO-1, CD 146 antibody-positive cells and LRCs significantly decreased compared with the control group.
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| Free Research Field |
顎関節疾患
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