epigenetic mechanism of osteoblastic bone formation in mechanical stress

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20576
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Tohoku University
• Principal Investigator: KERA YOUHEI 東北大学, 歯学研究科, 大学院非常勤講師 (90647950)
• Co-Investigator(Renkei-kenkyūsha): YAMAMOTO TERUKO 東北大学, 大学院歯学研究科, 名誉教授 (00127250) ; ITO ARATA 東北大学, 大学院歯学研究科, 大学院非常勤講師 (10805914)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: エピジェネティクス

Outline of Final Research Achievements

Osterix is essential transcription factor for osteoblast differentiation which promotes differentiation from preosteoblast to mature osteoblast by activation of several osteoblastic genes. In this study, we investigated mechanism of Osterix expression by Smad3 and MATII in mouse preosteobalastic cell line(MC3T3-E1 cell).Smad3 and MATII interact with each other and repress expression of Osterix. MATII is enzyme which has relation to transmethylation reactions involving histones, so these findings may suggest that this complex regulates Osterix through the mechanism including histone methylation.

Free Research Field

矯正歯科