Construction of efficient orthodontic movement under the occlusal hypofunctional condition focusing on VEGF / VEGFR

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20582
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: USUMI-FUJITA Risa 東京医科歯科大学, 歯学部附属病院, プロジェクト助教 (90706946)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 咬合刺激低下 / 廃用性萎縮 / 歯科矯正 / VEGF / LIPUS

Outline of Final Research Achievements

Reduced occlusal stimuli are widely known to induce atrophic changes in the periodontal ligament (PDL) and alveolar bone. When compared with that of functional teeth, the PDL in occlusal hypofunctional teeth is thinner and bone formation and density are lower. Mechanical stress plays an important role in the homeostasis of PDL and alveolar bone remodeling.In this study, it was assumed that low-intensity pulsed ultrasound (LIPUS) exposure has recovery effects on the hypofunctional PDL and interradicular alveolar bone (IRAB). According to the results of micro-CT and qRT-PCR analysis, LIPUS exposure reduced the atrophic changes of alveolar bone by inducing the upregulation of periostin and CTGF expression to promote PDL healing after induction of occlusal hypofunction.

Free Research Field

歯科矯正学