Elucidation of tissue colonization and pathogenesis of infective endocaritis-causing bacteria

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K20598
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Orthodontics/Pediatric dentistry
• Research Institution: Nagasaki University
• Principal Investigator: KONDO Yoshio 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (30581954)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 感染性心内膜炎 / レンサ球菌

Outline of Final Research Achievements

Infective endocarditis is an infectious disease that forms warts in the endocardium, and the causative bacteria are pointed out as oral cavity-derived virulence streptococci. In this study, we compared genomes with non-pathogenic strains and Streptococcus oralis strain NS308 isolated from endocarditis lesion, and investigated the involvement in pathogenicity. As a result of analysis using the next generation sequencer, it was possible to obtain a full-length genome sequence. Based on this, comparing of the non-pathogenic strain S. oralis Uo5 and NS308 revealed that there are 340 NS308-specific genes and 69 of which are foreign genes. It seems that these are related to the acquisition of the pathogenicity in this bacterium, and further investigation will be necessary.

Free Research Field

小児歯科学