2016 Fiscal Year Final Research Report
Analysis of the effect of ketone bodies on bone metabolism
| Project/Area Number |
15K20628
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | ケトン体 / 骨芽細胞 / 骨代謝 |
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| Outline of Final Research Achievements |
In this study, it was decided to investigate the mechanism of acetoacetate (AA) and b-hydroxybutyrate (HB) ALP activity / calcification formation regulation and its influence on osteoblast specific action.
It was found that AA and HB increased and suppressed ALP activity and calcification formation in a concentration-dependent and time-dependent manner in osteoblast-like cells MC3T3-E1 cells and primary osteoblasts.Furthermore, AA or HB was added to the medium during chondroblast-like cell ATDC5 cells and osteoclast-like cell RAW cell culture and the influence was analyzed. However, even when AA and HB were added, significance No change was seen.From this, it was found that AA and HB act on osteoblast specific.
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| Free Research Field |
歯周病
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