2016 Fiscal Year Final Research Report
Analysis of transcription factors involved in the differentiation induction of periodontal tissue constituent cells
| Project/Area Number |
15K20631
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontology
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| Research Institution | Nihon University |
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Principal Investigator |
TAKAI Hideki 日本大学, 松戸歯学部, 講師 (30453898)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 転写因子 |
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| Outline of Final Research Achievements |
Establishment of periodontal tissue regeneration therapy is important to understand the biological properties of the periodontal tissue component cells. We were searched HPDL is induced to what kinds of phenotype cells by suppressed the specifically expressed transcription factors at periodontal tissue. Result of suppression the specifically expressed transcription factor at periodontal tissue, siTwist2 increased Sox5 mRNA and protein levels. moreover, siKLF12 incresed Sox2 and KLF4 mRNA level, it increased KLF4 protein levels. we suggested that HPDL could be induced to different nature cell by suppressed the specifically expressed transcription factors at periodontal tissue.
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| Free Research Field |
歯周治療学
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