2017 Fiscal Year Final Research Report
Influence of aging on pain sensation in the trigeminal region.
| Project/Area Number |
15K20639
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 疼痛 / 加齢 / 三叉神経 |
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| Outline of Final Research Achievements |
The purpose of this study was to examine the influence of aging on pain sensation in the trigeminal region. Single neuronal activity corresponding to painful stimulation by Complete Freund’s adjuvant (CFA) in aged rats and adult rats was recorded. The number of phosphorylated extracellular signal–regulated kinases (pERK) positive cells in the trigeminal spinal sub-nucleus caudalis (Vc) and trigeminal spinal sub-nucleus interpolaris (Vi) regions was examined and compared over time. Experiments were also conducted on the effects of serotonin uptake inhibitors on pain response by CFA. In the Vi/Vc zone of the trigeminal spinal nucleus of adult rats, neuronal activity increased markedly due to pain stimulation by CFA. The number of pERK staining positive cells peaked at day 3 and significantly more on days 5 and 7 compared to day 2.
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| Free Research Field |
矯正歯科学
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