2016 Fiscal Year Annual Research Report
Elucidation of mechanisms by which host immune cells kill protozoan parasites and development of antiparasitic peptides
| Project/Area Number |
15K20840
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| Research Institution | Hokkaido University |
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Principal Investigator |
テルカウィ アラー 北海道大学, 医学研究科, 助教 (00723074)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | Macrophages / neutrophils / effector molecules / DNA Microarray / DEFB130 / CTSL |
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| Outline of Annual Research Achievements |
Understanding the molecular defense mechanism of phagocytes and identifying their effector molecules against malarial parasites may provide important clues for the discovery of new therapies. Macrophages and neutrophils are professional phagocytes that play key role in the innate immune response against infection through their ability to rapidly recognize and kill microorganisms. An attempt was made to identify the host effector molecules derived from macrophages and neutrophils that kill malaria parasites using DNA microarray technology.
Results suggested that DEFB130 from macrophages and CTSL from neutrophils are involved in the clearance mechanism of malarial parasites (Terkawi et al., 2017; Sci Rep & submitted to journal, respectively). The data obtained from this project broaden our knowledge on the immunological response of macrophages and neutrophils to malaria parasites and shed light on a new target for therapeutic intervention.
Bearing in mind the central role of our immune system in the human health and well-being, my current research is directed toward investigating the immunological responses to non-infectious substances (implant) lead to postoperative complications and harmful reaction in the tissue. Currently, my research aims to explore the precise molecular mechanism responsible for osteolysis and to identify a novel molecular target for better control strategy.
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Research Products
(2 results)
