Study of the mechanism of electrophile signaling regulation by reactive persulfide species

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K20855
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology; General pharmacology
• Research Institution: Tohoku University
• Principal Investigator: KASAMATSU Shingo 東北大学, 医学系研究科, 非常勤講師 (80738807)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 活性イオウ分子 / 親電子シグナル制御 / 酸化ストレス / 8-ニトロ-cGMP / メチル水銀

Outline of Final Research Achievements

We investigated the mechanism of neurotoxicity induced by environmental electrophile methylmercury focusing on the signal regulatory function of reactive persulfide species. We found that methylmercury exposure to cells induced depletion of intracellular reactive persulfides and subsequently evoked abnormal activation of signaling pathway mediated by endogenous signaling molecule 8-nitro-cGMP to cause neuronal death. The results of this study will contribute to the elucidation of the mechanism of toxic effect by environmental chemicals and physiological function of reactive persulfide species.

Free Research Field

生化学