2016 Fiscal Year Final Research Report
Investigation of antimicrobial activity of hypothalamic peptides in chronic bacterial infection
| Project/Area Number |
15K21002
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied health science
General internal medicine(including psychosomatic medicine)
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 非結核性抗酸菌症 / グレリン / 抗菌活性 |
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| Outline of Final Research Achievements |
According to some previous reports and characteristics of cationic charge, we investigated whether ghrelin possesses antibiotic effect on non-tuberculous mycobacteria. We used two strains of non-tuberculous mycobacteria, Mycobacterium avium 104 as a reference strain and M. intracellulare as a hypervirulent clinical strain. Contrary to our expectation, the number of bacteria increased in ghrelin concentration-dependent manner both in direct incubation and in macrophage infection. Furthermore, culture supernatant of adipocytes and myocytes treated with ghrelin also increased the number of bacteria, which contradicts the indirect antibiotic effect by inhibiting catabolism by ghrelin. These data suggests that ghrelin does not possess antibiotic effect on non-tuberculous mycobacteria.
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| Free Research Field |
細菌学
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