2016 Fiscal Year Final Research Report
Identification of miRNAs inducing synthetic lethality in ATL cells
| Project/Area Number |
15K21003
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
Tumor therapeutics
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| Research Institution | Aichi Gakuin University (2016)
Niigata University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | ATL / miRNA / HTLV-1 |
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| Outline of Final Research Achievements |
Adult T-cell leukemia (ATL) is caused by the infection with Human T-cell leukemia virus type I (HTLV-1). The patients with ATL show a poor prognosis. Effective treatment of ATL has not been established yet. In this project, we attempted to identify the miRNAs selectively affecting the viability of ATL cells. First, we employed a bioinformatics analysis to predict the miRNA which dominantly target the genes required for the survival of HTLV-I-transformed cells. The results of the computational prediction were verified in HTLV-1-transformed cells and HTLV-1-negative human T cell lines. Overexpression of miRNAs reduces the viability of HTLV-1-transformed cells but not HTLV-1-negative cells. These results suggest that certain miRNAs might be a novel therapeutic agent against ATL.
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| Free Research Field |
腫瘍学
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