Search for novel causative genes of familial and early onset gastric cancer using comprehensive copy number analysis

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K21054
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology; Tumor biology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Yamada Hidetaka 浜松医科大学, 医学部, 特任研究員 (30397400)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: 家族性胃がん / 若年性胃がん / 網羅的染色体コピー数解析 / 生殖細胞系列コピー数変化 / CDH1

Outline of Final Research Achievements

Comprehensive copy number analysis was performed for familial and early onset gastric cancer patients and relatives who were negative for germline mutations and copy number alterations in the CDH1 gene. In each family, 10 to 60 regions were detected as copy number variation (CNV) that may be involved in gastric carcinogenesis. CNVs of cancer-related gene were selected and investigated in healthy volunteers. CNVs of several apoptosis-related genes were revealed to cause in familial and early onset gastric cancer patients. This study was suggested that genes other than CDH1 gene were also involved in gastric carcinogenesis.

Free Research Field

実験病理