2017 Fiscal Year Final Research Report
Regulation of Ephrin receptor by inducible ubiquitin ligase SSB
Project/Area Number |
15K21056
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Biological pharmacy
General medical chemistry
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Research Institution | Nagoya University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | ユビキチン / EphB2 / 細胞間反発運動 / タンパク質分解 / SPSB4 |
Outline of Final Research Achievements |
We identified ephB2 receptor as SSB4 (SPSB4)-interacting protein. SPSB4 is a functionally unknown ubiquitin ligase.EphB2 is known to act as oncogene or tumuor suppressor depending on the cell type. We showed that SPSB4 destabilized EphB2 cytoplasmic domain. Next, we analyzed cell repulsive responses by co-culturing ephrin B2-expressing cells and EphB2-expressing cells.As a result, SPSB4 knock down enhanced cell repulsive responses and SPSB4 was shown to prevent EphB2 signaling pathway.
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Free Research Field |
タンパク質翻訳後修飾
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