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2017 Fiscal Year Final Research Report

Regulation of Ephrin receptor by inducible ubiquitin ligase SSB

Research Project

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Project/Area Number 15K21056
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
General medical chemistry
Research InstitutionNagoya University

Principal Investigator

Okumura Fumihiko  名古屋大学, 理学研究科, 講師 (00507212)

Project Period (FY) 2015-04-01 – 2018-03-31
Keywordsユビキチン / EphB2 / 細胞間反発運動 / タンパク質分解 / SPSB4
Outline of Final Research Achievements

We identified ephB2 receptor as SSB4 (SPSB4)-interacting protein. SPSB4 is a functionally unknown ubiquitin ligase.EphB2 is known to act as oncogene or tumuor suppressor depending on the cell type.
We showed that SPSB4 destabilized EphB2 cytoplasmic domain. Next, we analyzed cell repulsive responses by co-culturing ephrin B2-expressing cells and EphB2-expressing cells.As a result, SPSB4 knock down enhanced cell repulsive responses and SPSB4 was shown to prevent EphB2 signaling pathway.

Free Research Field

タンパク質翻訳後修飾

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Published: 2019-03-29  

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