2016 Fiscal Year Final Research Report
Free-designed muscle reconstruction by motoneuron transplantation in a free nerve graft
| Project/Area Number |
15K21059
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Research Collaborator |
SHIMODA Shingo 国立研究開発法人理化学研究所, 脳科学総合研究センター, 連携ユニットリーダー (20415186)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 末梢神経 / 運動機能再建 / 神経幹細胞移植 |
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| Outline of Final Research Achievements |
We established a technique to reconstruct the denervated muscle using free nerve graft as a carrier of transplanted cells. Embryonic ventral spinal cord cells were transplanted into free nerve graft and they constructed spinal cord-like structure consisting of central nervous system cells. In the histological and functional evaluation, the free nerve graft became an ectopic neural ganglion and reinnervated the denervated muscle as a new dominant nerve. Muscle contraction was also recognized by electrical stimulation. Moreover, we have been developing the stimulation electrode and coil for the non-contact stimulation. So, we could develop new technology contributing to regenerative medicine for paralyzed muscles.
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| Free Research Field |
末梢神経
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