2017 Fiscal Year Final Research Report
Role of cohesin in T cell development
| Project/Area Number |
15K21083
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
General medical chemistry
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | T細胞分化 / エピジェネティクス / 染色体高次構造 |
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| Outline of Final Research Achievements |
We generated Smc3 conditional knockout (cKO) mice, where the Smc3 locus could be deleted in various stages of T-lineages, and found that the cohesin is not essential for rearrangements of TCRb locus. Our data
shows that transcription factor E2A form foci in the nuclei of DN thymocytes, and that Vb regions come close to DJb regions near the E2A foci before the rearrangements of TCRb locus. These results suggest that E2A controls TCRb rearrangements by bringing Vb close to DJb on the E2A foci in DN thymocytes.
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| Free Research Field |
免疫学
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