Lipid-bilayer-assisted self-assembly of DNA origami arrays and their functionalization

2016 Fiscal Year Final Research Report

• Project/Area Number: 15K21093
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Nanobioscience; Nanostructural chemistry
• Research Institution: Tohoku University (2016); Kyoto University (2015)
• Principal Investigator: Suzuki Yuki 東北大学, 学際科学フロンティア研究所, 助教 (50636066)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Keywords: DNAナノテクノロジー / DNAオリガミ / 脂質二分子膜 / 自己集合化 / 自己組織化 / ボトムアップ技術 / 原子間力顕微鏡

Outline of Final Research Achievements

In this study, we established a method to self-assemble DNA origami nanostructures into two-dimensional crystalline structures on planar lipid bilayer membranes. By changing the shape of DNA nanostructures and designing interactions between the DNA nanostructures, various two-dimensional crystalline structures were constructed. The self-assembled structures can be modified with heterogeneous molecules and be used as a scaffold for periodic arrangement of protein molecules and other nanostructures.

Free Research Field

DNAナノテクノロジー