2016 Fiscal Year Final Research Report
Novel disease model of human inherited cancer syndromes using patient-derived iPS cells
| Project/Area Number |
15K21111
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
Experimental pathology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Keywords | 腫瘍学 / 遺伝性疾患 / がん抑制遺伝子 / VHL / 褐色細胞腫 |
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| Outline of Final Research Achievements |
Von Hippel-Lindau（VHL）disease is inherited cancer syndrome, which develop several types of cancers and/or is complicated by them. The aim of this project is to establish novel disease model of human VHL disease, and to elucidate the mechanism of the onset and/or the development of VHL disease using patient-derived iPS cells.
We developed the in vivo evaluation system to recapitulate VHL-associated cancers using NOD/SCID mice and new in vitro experimental method of the differentiation from iPS cells to the origins of VHL-associated cancers that there are no human cell lines. In addition, we selected some candidate target genes as useful for facilitating the differentiation to the origins of VHL-associated cancers.
These results suggested that in vivo and in vitro experimental methods as a basis for this project were established and we progressed forward the elucidation of the mechanism of the onset and/or the development of VHL disease.
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| Free Research Field |
分子腫瘍学、分子標的治療学
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