Animal model study for mechanisms of central poststroke pain and pain relieving effect with neurostimulation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K21142
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pain science; Neurosurgery
• Research Institution: Osaka University
• Principal Investigator: Hosomi Koichi 大阪大学, 医学系研究科, 特任講師(常勤) (70533800)
• Research Collaborator: SAITOH Youichi ; OKADA Kenichi ; KADONO Yoshinori
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 中枢性脳卒中後疼痛 / 動物疾患モデル / 視床痛 / 一次運動野刺激 / ニューロモデュレーション / 安静時fMRI / 反復経頭蓋磁気刺激

Outline of Final Research Achievements

We created a macaque model of central poststroke pain (CPSP), and investigated its behavior and brain function using a high magnetic field MRI. Functional connectivities between pain related brain regions increased after pain development. Primary motor cortex stimulation using repetitive transcranial magnetic stimulation (rTMS) alleviated hyperesthesia, and decreased functional connectivities between pain related brain regions. The findings from this study have suggested that the functional connectivity between pain related brain regions is involved in mechanisms of CPSP development and pain relief after rTMS.

Free Research Field

機能的脳神経外科