Molybdenum-Catalyzed Carbon-Hydrogen Bond Functionalization

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K21180
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Synthetic chemistry; Organic chemistry
• Research Institution: Okayama University
• Principal Investigator: Asako Sobi 岡山大学, 自然科学研究科, 助教 (80737289)
• Research Collaborator: ISHIKAWA Sae ; HAYASHI Miyuki ; ISHIHARA Seina ; HIRATA Keiya ; KOBASHI Takaaki
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: モリブデン / 炭素－水素結合切断 / 不活性結合活性化 / カルベン / インドール / ヒドロシリル化 / アレン

Outline of Final Research Achievements

The molybdenum-catalyzed deoxygenative cyclizations of carbonyl compounds through C(sp3)-H and C(sp2)-H bond cleavage have been developed, where the carbonyl carbon functions as a carbene equivalent. The molybdenum-catalyzed hydrosilylation of allenes for synthesis of linear allylsilanes has also been developed. The origin of the unprecedented linear selectivity was revealed by DFT studies. Both the reactions showed reactivity and selectivity unique to molybdenum.

Free Research Field

有機合成化学、有機金属化学